You have a patient with severe diarrhea and has been diagnosed with cholera, A disease transmitted through unsanitary water contaminated by a bacterium passed on in fecal matter from infected individuals. The toxin produced by cholera bacteria causes cl- channels in the membranes of intestinal cells to stay open thereby increasing the influx of cl- into the intestines, along with normally secreted amounts of NA+, which follows its concentration gradient from the blood stream into the intestines. Why would above described mechanism cause severe diarrhea?
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