Now I can actually diagnose the problem but I'm not savvy enough to find a solution.

I run 4 monitors. Monitor 3 is my big high end monitor that I run all my games off without any problems. 1920x1080 resolution.
I use a Dominator Pro laptop using a Dynadock to extend the screens. Video Card is Nvidia if that helps.

Now the actually problem is simple. On the laptop screen I can play any game to perfection. But when I use the high end monitor which is set to Main Screen I get a black screen, I get the audio and can do things. If I Alt-Tab out I get a windowed version that I can see everything and hear it. But obviously the moment I click on it I lose my visuals again. Far Cry 4, Star Wars Battlefront are some of the ones that do this problem. Starcraft 2 will run fine.

Would appreciate help.