Is it okay for Christians to play the Binding of Isaac?

You have not explained what you are talking about. Christians can do anything they think they should, and each person gets to decide for himself what that means. "Play" can mean anything. For instance, this "Binding of Isaac" might be a record or a movie, a video game, a part in a stage presentation, or several other things. So you just need to explain what you are talking about and exactly what the problem is.

1 Corinthians 10:23
All things are lawful for me, but all things are not expedient: all things are lawful for me, but all things edify not.